Drug interactions
Modafinil + Omeprazole
Severity: Minor
Modafinil and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil induces CYP3A4 and inhibits CYP2C19, so omeprazole exposure may rise through reduced CYP2C19 clearance. Modafinil labeling lists omeprazole as a CYP2C19 substrate whose levels may increase.
What this interaction means in plain words
Modafinil and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Modafinil inhibits CYP2C19, reducing omeprazole clearance.
What to do
Dose reduction is rarely needed; monitor for omeprazole adverse effects, especially at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Omeprazole?
MediHelp rates the interaction as minor. Modafinil and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil induces CYP3A4 and inhibits CYP2C19, so omeprazole exposure may rise through reduced CYP2C19 clearance. Modafinil labeling lists omeprazole as a CYP2C19 substrate whose levels may increase.
How serious is the interaction between Modafinil and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose reduction is rarely needed; monitor for omeprazole adverse effects, especially at high doses.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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