Drug interactions
Modafinil + Osimertinib
Severity: Moderate
Modafinil and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak to moderate CYP3A4 inducer and may reduce osimertinib concentrations. The clinical consequence would be potentially diminished anticancer effect.
What this interaction means in plain words
Modafinil and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Modafinil belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Modafinil induces CYP3A4, increasing osimertinib clearance.
What to do
Use an alternative wakefulness-promoting approach if possible. If co-prescribed, monitor for disease progression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Osimertinib
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Osimertinib?
MediHelp rates the interaction as moderate. Modafinil and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil is a weak to moderate CYP3A4 inducer and may reduce osimertinib concentrations. The clinical consequence would be potentially diminished anticancer effect.
How serious is the interaction between Modafinil and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative wakefulness-promoting approach if possible. If co-prescribed, monitor for disease progression.
What other medicines interact with Osimertinib?
MediHelp also lists interactions of Osimertinib with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Osimertinib page.
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