Drug interactions
Modafinil + Ospemifene
Severity: Minor
Modafinil and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak CYP3A4 inducer and a CYP2C19 inhibitor, and ospemifene is metabolized by both CYP3A4 and CYP2C19. The net effect on ospemifene exposure is uncertain and probably small.
What this interaction means in plain words
Modafinil and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Ospemifene belongs to Endocrine.
Why it happens
Modafinil modulates CYP2C19 and CYP3A4 metabolism of ospemifene, with an uncertain net effect.
What to do
No routine adjustment; assess ospemifene efficacy and tolerability if modafinil is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Modafinil with Ospemifene?
MediHelp rates the interaction as minor. Modafinil and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a weak CYP3A4 inducer and a CYP2C19 inhibitor, and ospemifene is metabolized by both CYP3A4 and CYP2C19. The net effect on ospemifene exposure is uncertain and probably small.
How serious is the interaction between Modafinil and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; assess ospemifene efficacy and tolerability if modafinil is started or stopped.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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