Drug interactions
Modafinil + Perphenazine
Severity: Minor
Modafinil and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is sedating and modafinil is stimulating, so the two have opposing effects on alertness. Modafinil may counter sedation but could worsen agitation or psychosis, and effects on perphenazine levels are not well defined.
What this interaction means in plain words
Modafinil and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Opposing CNS pharmacodynamic effects; modafinil's weak CYP2D6 and CYP induction effects are not clearly clinically relevant here.
What to do
No routine adjustment is needed. Monitor mental state and for loss of antipsychotic efficacy or extrapyramidal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Modafinil with Perphenazine?
MediHelp rates the interaction as minor. Modafinil and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine is sedating and modafinil is stimulating, so the two have opposing effects on alertness. Modafinil may counter sedation but could worsen agitation or psychosis, and effects on perphenazine levels are not well defined.
How serious is the interaction between Modafinil and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor mental state and for loss of antipsychotic efficacy or extrapyramidal effects.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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