Drug interactions
Modafinil + Ribociclib
Severity: Minor
Modafinil and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and could increase modafinil concentrations, since CYP3A4 contributes to modafinil clearance. The expected effect is a mild increase in modafinil adverse effects.
What this interaction means in plain words
Modafinil and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated modafinil metabolism by ribociclib.
What to do
No routine dose adjustment is needed. Watch for increased modafinil effects such as insomnia, anxiety and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Modafinil with Ribociclib?
MediHelp rates the interaction as minor. Modafinil and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and could increase modafinil concentrations, since CYP3A4 contributes to modafinil clearance. The expected effect is a mild increase in modafinil adverse effects.
How serious is the interaction between Modafinil and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Watch for increased modafinil effects such as insomnia, anxiety and headache.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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