Drug interactions
Modafinil + Temazepam
Severity: Minor
Modafinil and Temazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness while temazepam is a sedative-hypnotic, so their clinical effects oppose each other. Modafinil may weaken the intended hypnotic effect, and it can also mask sedation without removing benzodiazepine-related psychomotor impairment. Modafinil has a weak CYP3A4 inducing effect, but temazepam is mainly glucuronidated so this is of little relevance.
What this interaction means in plain words
Modafinil and Temazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; no significant pharmacokinetic interaction is expected.
What to do
Avoid dosing modafinil close to bedtime when temazepam is used for insomnia. Counsel patients that perceived alertness does not guarantee restored psychomotor performance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Modafinil with Temazepam?
MediHelp rates the interaction as minor. Modafinil and Temazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness while temazepam is a sedative-hypnotic, so their clinical effects oppose each other. Modafinil may weaken the intended hypnotic effect, and it can also mask sedation without removing benzodiazepine-related psychomotor impairment. Modafinil has a weak CYP3A4 inducing effect, but temazepam is mainly glucuronidated so this is of little relevance.
How serious is the interaction between Modafinil and Temazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dosing modafinil close to bedtime when temazepam is used for insomnia. Counsel patients that perceived alertness does not guarantee restored psychomotor performance.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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