Drug interactions
Modafinil + Voriconazole
Severity: Minor
Modafinil and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise modafinil concentrations through inhibition of its CYP3A4-mediated metabolism. This could increase adverse effects such as headache, anxiety, insomnia, or tachycardia. Modafinil is a weak CYP3A4 inducer, so its effect on voriconazole is likely small.
What this interaction means in plain words
Modafinil and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Modafinil belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, and also CYP2C19, which contribute to modafinil clearance.
What to do
Monitor for modafinil adverse effects such as insomnia, agitation and palpitations and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Modafinil with Voriconazole?
MediHelp rates the interaction as minor. Modafinil and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may raise modafinil concentrations through inhibition of its CYP3A4-mediated metabolism. This could increase adverse effects such as headache, anxiety, insomnia, or tachycardia. Modafinil is a weak CYP3A4 inducer, so its effect on voriconazole is likely small.
How serious is the interaction between Modafinil and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects such as insomnia, agitation and palpitations and reduce the dose if they occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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