Drug interactions
Momelotinib + Sulphasalazine
Severity: Moderate
Momelotinib and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP, and sulfasalazine is a sensitive BCRP substrate. Concurrent use may raise sulfasalazine levels and increase the risk of its adverse reactions.
What this interaction means in plain words
Momelotinib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Momelotinib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Momelotinib inhibits BCRP efflux transport, increasing sulfasalazine bioavailability.
What to do
Monitor for sulfasalazine adverse effects and blood counts, and consider lowering the sulfasalazine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Momelotinib with Sulphasalazine?
MediHelp rates the interaction as moderate. Momelotinib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib inhibits BCRP, and sulfasalazine is a sensitive BCRP substrate. Concurrent use may raise sulfasalazine levels and increase the risk of its adverse reactions.
How serious is the interaction between Momelotinib and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine adverse effects and blood counts, and consider lowering the sulfasalazine dose if toxicity develops.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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