Drug interactions
Mometasone + Ribociclib
Severity: Minor
Mometasone and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may increase systemic exposure to mometasone. The clinical effect is likely modest with inhaled dosing but could lead to corticosteroid side effects with prolonged use.
What this interaction means in plain words
Mometasone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mometasone belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of mometasone may modestly raise systemic levels.
What to do
Monitor for signs of systemic corticosteroid excess during long-term co-use. Reduce the mometasone dose if such effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Mometasone with Ribociclib?
MediHelp rates the interaction as minor. Mometasone and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may increase systemic exposure to mometasone. The clinical effect is likely modest with inhaled dosing but could lead to corticosteroid side effects with prolonged use.
How serious is the interaction between Mometasone and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during long-term co-use. Reduce the mometasone dose if such effects appear.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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