Drug interactions
Montelukast + Rifapentine
Severity: Moderate
Montelukast and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is a potent enzyme inducer and may lower montelukast concentrations. Loss of asthma control is possible, especially during prolonged tuberculosis therapy.
What this interaction means in plain words
Montelukast and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Montelukast belongs to Respiratory; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 and CYP2C8/2C9, enhancing montelukast clearance.
What to do
Monitor asthma control during and after rifapentine therapy and escalate asthma treatment if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Montelukast with Rifapentine?
MediHelp rates the interaction as moderate. Montelukast and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine is a potent enzyme inducer and may lower montelukast concentrations. Loss of asthma control is possible, especially during prolonged tuberculosis therapy.
How serious is the interaction between Montelukast and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control during and after rifapentine therapy and escalate asthma treatment if control worsens.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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