Drug interactions
Montelukast + Sparsentan
Severity: Minor
Montelukast and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP3A4 and may modestly lower exposure to drugs cleared by this route, including partly montelukast. Because the main pathway for montelukast is CYP2C8 and the effect is expected to be small, clinical significance is limited.
What this interaction means in plain words
Montelukast and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Montelukast belongs to Respiratory; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan is a weak inducer of CYP3A4 and possibly CYP2C enzymes, increasing montelukast clearance.
What to do
No dose change is routinely required; watch for loss of asthma or allergy control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Montelukast with Sparsentan?
MediHelp rates the interaction as minor. Montelukast and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan induces CYP3A4 and may modestly lower exposure to drugs cleared by this route, including partly montelukast. Because the main pathway for montelukast is CYP2C8 and the effect is expected to be small, clinical significance is limited.
How serious is the interaction between Montelukast and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; watch for loss of asthma or allergy control.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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