Drug interactions
Montelukast + Voxelotor
Severity: Minor
Montelukast and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise exposure to sensitive CYP3A4 substrates. Montelukast is not primarily a CYP3A4 substrate and has a wide therapeutic margin, so a significant effect is unlikely.
What this interaction means in plain words
Montelukast and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Montelukast belongs to Respiratory; Voxelotor belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition by voxelotor affects a minor montelukast clearance pathway.
What to do
No dose adjustment is needed; monitor for montelukast adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Montelukast with Voxelotor?
MediHelp rates the interaction as minor. Montelukast and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may raise exposure to sensitive CYP3A4 substrates. Montelukast is not primarily a CYP3A4 substrate and has a wide therapeutic margin, so a significant effect is unlikely.
How serious is the interaction between Montelukast and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for montelukast adverse effects.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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