Drug interactions
Moxifloxacin + Ozanimod
Severity: Major
Moxifloxacin and Ozanimod: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow the heart rate and delay AV conduction, and moxifloxacin prolongs the QT interval. Bradycardia increases the risk of torsades de pointes with QT-prolonging drugs.
What this interaction means in plain words
Moxifloxacin and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moxifloxacin belongs to Anti Bacterial; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: S1P-mediated bradycardia plus moxifloxacin-induced QT prolongation.
What to do
Avoid starting ozanimod in patients on QT-prolonging drugs unless the benefit outweighs the risk, and obtain cardiology advice and an ECG first. Prefer a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Ozanimod?
MediHelp rates the interaction as major. Moxifloxacin and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod can slow the heart rate and delay AV conduction, and moxifloxacin prolongs the QT interval. Bradycardia increases the risk of torsades de pointes with QT-prolonging drugs.
How serious is the interaction between Moxifloxacin and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients on QT-prolonging drugs unless the benefit outweighs the risk, and obtain cardiology advice and an ECG first. Prefer a non-QT-prolonging antibiotic.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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