Drug interactions
Moxifloxacin + Risperidone
Severity: Major
Moxifloxacin and Risperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QT interval, and their combination may increase the likelihood of torsades de pointes. Risk is higher in older patients, those with cardiac disease, bradycardia or hypokalemia.
What this interaction means in plain words
Moxifloxacin and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moxifloxacin belongs to Anti Bacterial; Risperidone belongs to Central Nervous System.
Why it happens
Additive IKr (hERG) channel inhibition causing delayed cardiac repolarization.
What to do
Choose a non-QT-prolonging antibiotic when possible. If used together, check a baseline ECG, correct electrolytes and monitor for QTc lengthening or arrhythmia symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Moxifloxacin with Risperidone?
MediHelp rates the interaction as major. Moxifloxacin and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QT interval, and their combination may increase the likelihood of torsades de pointes. Risk is higher in older patients, those with cardiac disease, bradycardia or hypokalemia.
How serious is the interaction between Moxifloxacin and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-QT-prolonging antibiotic when possible. If used together, check a baseline ECG, correct electrolytes and monitor for QTc lengthening or arrhythmia symptoms.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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