Drug interactions
Moxifloxacin + Sevoflurane
Severity: Moderate
Moxifloxacin and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval, and moxifloxacin has a similar effect, so perioperative use together may raise the risk of torsades de pointes. Patients with congenital or acquired long QT are at greatest risk.
What this interaction means in plain words
Moxifloxacin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Review the preoperative ECG and correct electrolytes. Monitor the ECG perioperatively in at-risk patients, or choose another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Moxifloxacin with Sevoflurane?
MediHelp rates the interaction as moderate. Moxifloxacin and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane prolongs the QT interval, and moxifloxacin has a similar effect, so perioperative use together may raise the risk of torsades de pointes. Patients with congenital or acquired long QT are at greatest risk.
How serious is the interaction between Moxifloxacin and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and correct electrolytes. Monitor the ECG perioperatively in at-risk patients, or choose another antibiotic.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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