Drug interactions
Moxifloxacin + Tiotropium-olodaterol
Severity: Moderate
Moxifloxacin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is among the fluoroquinolones with more marked QT prolongation, and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation. This can lead to torsades de pointes in susceptible patients.
What this interaction means in plain words
Moxifloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and cardiac stimulation.
What to do
Correct potassium and magnesium before and during therapy and obtain an ECG in patients with cardiac risk factors. Consider an alternative antibiotic in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Moxifloxacin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin is among the fluoroquinolones with more marked QT prolongation, and olodaterol may add to arrhythmia risk through hypokalemia and sympathetic stimulation. This can lead to torsades de pointes in susceptible patients.
How serious is the interaction between Moxifloxacin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy and obtain an ECG in patients with cardiac risk factors. Consider an alternative antibiotic in patients with known QT prolongation.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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