Drug interactions
Moxifloxacin + Trimipramine
Severity: Major
Moxifloxacin and Trimipramine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and using them together adds to the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia, or underlying heart disease.
What this interaction means in plain words
Moxifloxacin and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Moxifloxacin belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac potassium (hERG) channels leading to delayed ventricular repolarization.
What to do
Avoid the combination where an alternative antibiotic is available. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Avelox 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: tricyclic antidepressive agents; "tricyclic antidepressive agents") — electronic medicines compendium (UK SmPC)
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Trimipramine?
MediHelp rates the interaction as major. Moxifloxacin and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and using them together adds to the risk of torsades de pointes and other serious ventricular arrhythmias. The risk is greater with electrolyte disturbances, bradycardia, or underlying heart disease.
How serious is the interaction between Moxifloxacin and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic is available. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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