Drug interactions
Moxifloxacin + Valbenazine
Severity: Moderate
Moxifloxacin and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin is a known QT-prolonging drug, and valbenazine can prolong the QT interval at higher exposures. Used together they may add to the risk of torsades de pointes, especially with bradycardia or low potassium or magnesium.
What this interaction means in plain words
Moxifloxacin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moxifloxacin belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Check baseline ECG and electrolytes and correct any deficits. Monitor for palpitations or syncope, and consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Moxifloxacin with Valbenazine?
MediHelp rates the interaction as moderate. Moxifloxacin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin is a known QT-prolonging drug, and valbenazine can prolong the QT interval at higher exposures. Used together they may add to the risk of torsades de pointes, especially with bradycardia or low potassium or magnesium.
How serious is the interaction between Moxifloxacin and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and correct any deficits. Monitor for palpitations or syncope, and consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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