Drug interactions
Mycophenolate mofetil + Ocrelizumab
Severity: Moderate
Mycophenolate mofetil and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells and mycophenolate suppresses lymphocyte proliferation, so combined use may increase the risk of serious infections. The risk may persist for months after ocrelizumab is stopped.
What this interaction means in plain words
Mycophenolate mofetil and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression from B-cell depletion and inhibition of lymphocyte proliferation.
What to do
Assess infection risk before combining and monitor for infections, including viral reactivation. Consider checking immunoglobulin levels and lymphocyte counts during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Mycophenolate mofetil with Ocrelizumab?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells and mycophenolate suppresses lymphocyte proliferation, so combined use may increase the risk of serious infections. The risk may persist for months after ocrelizumab is stopped.
How serious is the interaction between Mycophenolate mofetil and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess infection risk before combining and monitor for infections, including viral reactivation. Consider checking immunoglobulin levels and lymphocyte counts during treatment.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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