Drug interactions
Mycophenolate mofetil + Ozanimod
Severity: Moderate
Mycophenolate mofetil and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents reduce immune function, and combining them may raise the risk of infection. Ozanimod lowers circulating lymphocytes, and its effect persists for weeks after stopping.
What this interaction means in plain words
Mycophenolate mofetil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mycophenolate mofetil belongs to Miscellaneous; Ozanimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression: S1P receptor modulation sequesters lymphocytes while mycophenolate inhibits lymphocyte proliferation.
What to do
Monitor for infection and check lymphocyte and blood counts. Consider the prolonged immune effects when switching therapies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Mycophenolate mofetil with Ozanimod?
MediHelp rates the interaction as moderate. Mycophenolate mofetil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents reduce immune function, and combining them may raise the risk of infection. Ozanimod lowers circulating lymphocytes, and its effect persists for weeks after stopping.
How serious is the interaction between Mycophenolate mofetil and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check lymphocyte and blood counts. Consider the prolonged immune effects when switching therapies.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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