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Drug interactions

Mycophenolate mofetil + Temsirolimus

Severity: Major

Mycophenolate mofetil and Temsirolimus: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Both drugs suppress immune function, so combined use increases the risk of infection, including opportunistic infections. Cytopenias may also be additive.

What this interaction means in plain words

Mycophenolate mofetil and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Mycophenolate mofetil belongs to Miscellaneous; Temsirolimus belongs to Oncology.

Evidence level: Low

Why it happens

Additive immunosuppression through mTOR inhibition (temsirolimus) and IMPDH inhibition (mycophenolate).

What to do

Avoid combining unless clearly necessary; if used, monitor blood counts and infection signs closely and consider prophylaxis per local practice.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Mycophenolate mofetil with Temsirolimus?

MediHelp rates the interaction as major. Mycophenolate mofetil and Temsirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs suppress immune function, so combined use increases the risk of infection, including opportunistic infections. Cytopenias may also be additive.

How serious is the interaction between Mycophenolate mofetil and Temsirolimus?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless clearly necessary; if used, monitor blood counts and infection signs closely and consider prophylaxis per local practice.

What other medicines interact with Mycophenolate mofetil?

MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.

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