Drug interactions
Nabilone + Oxycodone
Severity: Major
Nabilone and Oxycodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and cannabinoids both depress the CNS, and together they may produce excessive drowsiness, confusion and impaired psychomotor function. Respiratory depression from oxycodone may be potentiated.
What this interaction means in plain words
Nabilone and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nabilone belongs to Gastrointestinal Tract; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate, particularly when starting or increasing either drug. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabilone
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Nabilone with Oxycodone?
MediHelp rates the interaction as major. Nabilone and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and cannabinoids both depress the CNS, and together they may produce excessive drowsiness, confusion and impaired psychomotor function. Respiratory depression from oxycodone may be potentiated.
How serious is the interaction between Nabilone and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, particularly when starting or increasing either drug. Counsel patients to avoid alcohol and driving.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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