Drug interactions
Nabilone + Sevoflurane
Severity: Moderate
Nabilone and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane is a general anesthetic, and nabilone has sedative effects that can add to anesthetic depth. Patients taking nabilone may need less anesthetic and may show prolonged sedation or hemodynamic changes in the perioperative period.
What this interaction means in plain words
Nabilone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of cannabinoid agonism and volatile anesthetic action.
What to do
Tell the anesthesia team about nabilone use before surgery. Titrate anesthetic to effect, monitor depth of anesthesia and hemodynamics, and watch for delayed recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nabilone and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabilone
Other interactions of Sevoflurane
Frequently asked questions
Can I take Nabilone with Sevoflurane?
MediHelp rates the interaction as moderate. Nabilone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane is a general anesthetic, and nabilone has sedative effects that can add to anesthetic depth. Patients taking nabilone may need less anesthetic and may show prolonged sedation or hemodynamic changes in the perioperative period.
How serious is the interaction between Nabilone and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about nabilone use before surgery. Titrate anesthetic to effect, monitor depth of anesthesia and hemodynamics, and watch for delayed recovery.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
