Drug interactions
Nabilone + Tramadol
Severity: Moderate
Nabilone and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone and tramadol both cause sedation and cognitive impairment. Together they may increase drowsiness, dizziness and respiratory depression, and tramadol also lowers the seizure threshold.
What this interaction means in plain words
Nabilone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from cannabinoid and opioid receptor activity.
What to do
Start with low doses and titrate cautiously. Monitor sedation, respiratory rate and mental status, and advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Nabilone with Tramadol?
MediHelp rates the interaction as moderate. Nabilone and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone and tramadol both cause sedation and cognitive impairment. Together they may increase drowsiness, dizziness and respiratory depression, and tramadol also lowers the seizure threshold.
How serious is the interaction between Nabilone and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate cautiously. Monitor sedation, respiratory rate and mental status, and advise against driving until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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