Drug interactions
Nabilone + Trazodone
Severity: Moderate
Nabilone and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is a sedating antidepressant, and nabilone adds to its drowsiness and psychomotor impairment. Both can also cause orthostatic hypotension and dizziness, raising the risk of falls, particularly in older adults.
What this interaction means in plain words
Nabilone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Trazodone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression and hypotensive effects.
What to do
Use the lowest effective doses, preferably giving trazodone at bedtime. Monitor sedation and orthostatic blood pressure, and counsel on fall risk and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Nabilone with Trazodone?
MediHelp rates the interaction as moderate. Nabilone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is a sedating antidepressant, and nabilone adds to its drowsiness and psychomotor impairment. Both can also cause orthostatic hypotension and dizziness, raising the risk of falls, particularly in older adults.
How serious is the interaction between Nabilone and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, preferably giving trazodone at bedtime. Monitor sedation and orthostatic blood pressure, and counsel on fall risk and driving.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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