Drug interactions
Nabilone + Trimipramine
Severity: Moderate
Nabilone and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic antidepressant with anticholinergic activity. Nabilone adds to sedation and can cause tachycardia and hypotension, so the combination may increase drowsiness, confusion and cardiovascular effects.
What this interaction means in plain words
Nabilone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with overlapping tachycardic and hypotensive effects of the two drugs.
What to do
Monitor sedation, heart rate and blood pressure, and use low starting doses. Lower the dose of either drug if oversedation or marked tachycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Nabilone with Trimipramine?
MediHelp rates the interaction as moderate. Nabilone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a sedating tricyclic antidepressant with anticholinergic activity. Nabilone adds to sedation and can cause tachycardia and hypotension, so the combination may increase drowsiness, confusion and cardiovascular effects.
How serious is the interaction between Nabilone and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and blood pressure, and use low starting doses. Lower the dose of either drug if oversedation or marked tachycardia occurs.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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