Drug interactions
Nabumetone + Trazodone
Severity: Moderate
Nabumetone and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that can impair platelet aggregation, and combined with an NSAID this increases the risk of bleeding, especially from the upper gastrointestinal tract. The risk is higher in older patients and those with prior ulcers or on anticoagulants.
What this interaction means in plain words
Nabumetone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabumetone belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition depletes platelet serotonin and impairs aggregation, while NSAIDs add platelet inhibition and gastric mucosal injury.
What to do
Watch for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Nabumetone with Trazodone?
MediHelp rates the interaction as moderate. Nabumetone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that can impair platelet aggregation, and combined with an NSAID this increases the risk of bleeding, especially from the upper gastrointestinal tract. The risk is higher in older patients and those with prior ulcers or on anticoagulants.
How serious is the interaction between Nabumetone and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of gastrointestinal bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Use the lowest effective NSAID dose for the shortest period.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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