Drug interactions
Nadolol + Propofol
Severity: Moderate
Nadolol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol causes vasodilation and myocardial depression, while nadolol blunts heart rate and contractility. Together they can cause more pronounced hypotension and bradycardia during induction or sedation.
What this interaction means in plain words
Nadolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Propofol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiovascular depression, with beta-blockade limiting compensatory tachycardia.
What to do
Monitor blood pressure and heart rate continuously and give propofol in slowly titrated, reduced doses. Have fluids and vasopressors or anticholinergics available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Propofol?
MediHelp rates the interaction as moderate. Nadolol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol causes vasodilation and myocardial depression, while nadolol blunts heart rate and contractility. Together they can cause more pronounced hypotension and bradycardia during induction or sedation.
How serious is the interaction between Nadolol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously and give propofol in slowly titrated, reduced doses. Have fluids and vasopressors or anticholinergics available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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