Drug interactions
Nadolol + Tucatinib
Severity: Moderate
Nadolol and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein, and nadolol is a substrate of this transporter, so its exposure may increase. This may lead to enhanced beta-blockade such as bradycardia or hypotension.
What this interaction means in plain words
Nadolol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nadolol belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibition of intestinal P-glycoprotein efflux increases nadolol absorption and exposure.
What to do
Monitor heart rate and blood pressure when starting tucatinib, and reduce the nadolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Nadolol with Tucatinib?
MediHelp rates the interaction as moderate. Nadolol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein, and nadolol is a substrate of this transporter, so its exposure may increase. This may lead to enhanced beta-blockade such as bradycardia or hypotension.
How serious is the interaction between Nadolol and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting tucatinib, and reduce the nadolol dose if bradycardia or hypotension develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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