Drug interactions
Naldemedine + Posaconazole
Severity: Moderate
Naldemedine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase naldemedine concentrations, potentially increasing opioid-withdrawal-like gastrointestinal effects such as abdominal pain, diarrhea and nausea. The effect is usually manageable.
What this interaction means in plain words
Naldemedine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naldemedine belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 and P-glycoprotein, both of which contribute to naldemedine clearance and absorption.
What to do
Monitor for gastrointestinal adverse effects and signs of opioid withdrawal; no routine dose change is needed, but consider reducing or stopping naldemedine if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Posaconazole?
MediHelp rates the interaction as moderate. Naldemedine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase naldemedine concentrations, potentially increasing opioid-withdrawal-like gastrointestinal effects such as abdominal pain, diarrhea and nausea. The effect is usually manageable.
How serious is the interaction between Naldemedine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and signs of opioid withdrawal; no routine dose change is needed, but consider reducing or stopping naldemedine if symptoms develop.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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