Drug interactions
Naldemedine + Progesterone
Severity: Minor
Naldemedine and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone may inhibit P-glycoprotein and slightly raise naldemedine exposure. The clinical impact is likely limited to gastrointestinal adverse effects.
What this interaction means in plain words
Naldemedine and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Progesterone belongs to Endocrine.
Why it happens
Possible P-glycoprotein inhibition by progesterone reducing naldemedine efflux.
What to do
No dose change is needed; monitor for abdominal pain and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Progesterone?
MediHelp rates the interaction as minor. Naldemedine and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone may inhibit P-glycoprotein and slightly raise naldemedine exposure. The clinical impact is likely limited to gastrointestinal adverse effects.
How serious is the interaction between Naldemedine and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for abdominal pain and diarrhea.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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