Drug interactions
Naratriptan + Vilazodone
Severity: Moderate
Naratriptan and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, and using them together raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity. The risk is greatest at the start of treatment or after dose increases.
What this interaction means in plain words
Naratriptan and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from vilazodone (SSRI and 5-HT1A partial agonist) and naratriptan (5-HT1B/1D agonist).
What to do
If the combination is needed, counsel the patient on serotonin syndrome symptoms and monitor closely, especially after starting or raising doses. Stop both drugs and give supportive care if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Vilazodone?
MediHelp rates the interaction as moderate. Naratriptan and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, and using them together raises the risk of serotonin syndrome, with agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity. The risk is greatest at the start of treatment or after dose increases.
How serious is the interaction between Naratriptan and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is needed, counsel the patient on serotonin syndrome symptoms and monitor closely, especially after starting or raising doses. Stop both drugs and give supportive care if symptoms develop.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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