Drug interactions
Nelfinavir + Silodosin
Severity: Major
Nelfinavir and Silodosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir is a moderate to strong CYP3A4 inhibitor and also affects P-gp. It can increase silodosin exposure and the risk of orthostatic hypotension and syncope.
What this interaction means in plain words
Nelfinavir and Silodosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nelfinavir belongs to Anti Virals; Silodosin belongs to Genitourinary.
Why it happens
Nelfinavir inhibits CYP3A4 and P-gp, reducing silodosin clearance.
What to do
Avoid the combination if possible and use an alternative alpha-blocker. If used, monitor blood pressure and orthostatic symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nelfinavir and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Silodosin?
MediHelp rates the interaction as major. Nelfinavir and Silodosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir is a moderate to strong CYP3A4 inhibitor and also affects P-gp. It can increase silodosin exposure and the risk of orthostatic hypotension and syncope.
How serious is the interaction between Nelfinavir and Silodosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative alpha-blocker. If used, monitor blood pressure and orthostatic symptoms closely.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
