Drug interactions
Neomycin + Pentamidine
Severity: Moderate
Neomycin and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine is itself nephrotoxic when given systemically. Oral neomycin is poorly absorbed but can reach systemic levels with gut mucosal damage or renal dysfunction, which adds to renal injury risk.
What this interaction means in plain words
Neomycin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive nephrotoxicity from two renally toxic drugs.
What to do
Monitor serum creatinine and electrolytes during co-therapy. Avoid the combination in patients with existing renal impairment or inflamed bowel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Neomycin with Pentamidine?
MediHelp rates the interaction as moderate. Neomycin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine is itself nephrotoxic when given systemically. Oral neomycin is poorly absorbed but can reach systemic levels with gut mucosal damage or renal dysfunction, which adds to renal injury risk.
How serious is the interaction between Neomycin and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes during co-therapy. Avoid the combination in patients with existing renal impairment or inflamed bowel.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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