Drug interactions
Neomycin + Zoledronic acid
Severity: Minor
Neomycin and Zoledronic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zoledronic acid lowers serum calcium, and aminoglycosides can cause renal magnesium and calcium wasting, so combined use may produce additive hypocalcemia. With oral neomycin, systemic absorption is low, so the risk is greatest with impaired gut integrity or renal impairment, and zoledronic acid is also nephrotoxic.
What this interaction means in plain words
Neomycin and Zoledronic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Neomycin belongs to Anti Bacterial; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic lowering of serum calcium and potential additive renal effects.
What to do
Monitor serum calcium, magnesium and renal function when used together, particularly in patients with renal impairment or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
Frequently asked questions
Can I take Neomycin with Zoledronic acid?
MediHelp rates the interaction as minor. Neomycin and Zoledronic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zoledronic acid lowers serum calcium, and aminoglycosides can cause renal magnesium and calcium wasting, so combined use may produce additive hypocalcemia. With oral neomycin, systemic absorption is low, so the risk is greatest with impaired gut integrity or renal impairment, and zoledronic acid is also nephrotoxic.
How serious is the interaction between Neomycin and Zoledronic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium, magnesium and renal function when used together, particularly in patients with renal impairment or prolonged neomycin use.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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