Drug interactions
Nevirapine + Nisoldipine
Severity: Moderate
Nevirapine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may substantially lower nisoldipine concentrations, reducing blood pressure control. Nisoldipine has very high first-pass metabolism, making it sensitive to induction.
What this interaction means in plain words
Nevirapine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Nisoldipine belongs to Cardiovascular.
Why it happens
Nevirapine induces intestinal and hepatic CYP3A4, increasing nisoldipine metabolism.
What to do
Monitor blood pressure and titrate nisoldipine upward as needed, or switch to a less CYP3A4-dependent antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nevirapine with Nisoldipine?
MediHelp rates the interaction as moderate. Nevirapine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may substantially lower nisoldipine concentrations, reducing blood pressure control. Nisoldipine has very high first-pass metabolism, making it sensitive to induction.
How serious is the interaction between Nevirapine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nisoldipine upward as needed, or switch to a less CYP3A4-dependent antihypertensive.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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