Drug interactions
Nevirapine + Osilodrostat
Severity: Moderate
Nevirapine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower osilodrostat concentrations by enzyme induction, potentially reducing control of cortisol. The effect is predicted and not well studied.
What this interaction means in plain words
Nevirapine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Osilodrostat belongs to Endocrine.
Why it happens
Nevirapine induces hepatic enzymes including CYP2B6, increasing osilodrostat clearance.
What to do
Monitor cortisol levels and clinical signs of hypercortisolism. Adjust the osilodrostat dose if needed, and reassess after stopping nevirapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Nevirapine with Osilodrostat?
MediHelp rates the interaction as moderate. Nevirapine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower osilodrostat concentrations by enzyme induction, potentially reducing control of cortisol. The effect is predicted and not well studied.
How serious is the interaction between Nevirapine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cortisol levels and clinical signs of hypercortisolism. Adjust the osilodrostat dose if needed, and reassess after stopping nevirapine.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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