Drug interactions
Nevirapine + Ospemifene
Severity: Moderate
Nevirapine and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower ospemifene exposure. Reduced ospemifene levels could weaken its effect on vulvovaginal atrophy symptoms.
What this interaction means in plain words
Nevirapine and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Ospemifene belongs to Endocrine.
Why it happens
Nevirapine induces CYP3A4 and CYP2C19, which increases the metabolic clearance of ospemifene.
What to do
Monitor for loss of symptom relief and consider an alternative therapy if efficacy is inadequate. Avoid the combination if a response cannot be maintained.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Nevirapine with Ospemifene?
MediHelp rates the interaction as moderate. Nevirapine and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower ospemifene exposure. Reduced ospemifene levels could weaken its effect on vulvovaginal atrophy symptoms.
How serious is the interaction between Nevirapine and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom relief and consider an alternative therapy if efficacy is inadequate. Avoid the combination if a response cannot be maintained.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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