Drug interactions
Nevirapine + Saxagliptin
Severity: Minor
Nevirapine and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saxagliptin is metabolized by CYP3A4/5 to an active metabolite, so nevirapine may alter its exposure. The clinical effect on glycemic control is expected to be small.
What this interaction means in plain words
Nevirapine and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Saxagliptin belongs to Endocrine.
Why it happens
CYP3A4 induction by nevirapine increases saxagliptin metabolism.
What to do
Monitor glycemic control when nevirapine is started or stopped; no empirical dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Nevirapine with Saxagliptin?
MediHelp rates the interaction as minor. Nevirapine and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saxagliptin is metabolized by CYP3A4/5 to an active metabolite, so nevirapine may alter its exposure. The clinical effect on glycemic control is expected to be small.
How serious is the interaction between Nevirapine and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when nevirapine is started or stopped; no empirical dose change is usually required.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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