Drug interactions
Nevirapine + Solifenacin
Severity: Moderate
Nevirapine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may reduce solifenacin concentrations, which could lessen its effect on bladder symptoms. The consequence is reduced efficacy rather than toxicity.
What this interaction means in plain words
Nevirapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Solifenacin belongs to Genitourinary.
Why it happens
Induction of CYP3A4 metabolism of solifenacin by nevirapine.
What to do
Monitor for reduced symptom control and titrate solifenacin to response within the labeled maximum, or consider an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Solifenacin?
MediHelp rates the interaction as moderate. Nevirapine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may reduce solifenacin concentrations, which could lessen its effect on bladder symptoms. The consequence is reduced efficacy rather than toxicity.
How serious is the interaction between Nevirapine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and titrate solifenacin to response within the labeled maximum, or consider an alternative agent.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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