Drug interactions
Nevirapine + Tipranavir
Severity: Moderate
Nevirapine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower tipranavir exposure, though the effect is not well characterized. Immune reconstitution syndrome can occur with antiretroviral therapy in general.
What this interaction means in plain words
Nevirapine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing metabolism of tipranavir.
What to do
Monitor HIV viral load and liver enzymes. Watch for inflammatory symptoms of immune reconstitution after starting therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Nevirapine with Tipranavir?
MediHelp rates the interaction as moderate. Nevirapine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower tipranavir exposure, though the effect is not well characterized. Immune reconstitution syndrome can occur with antiretroviral therapy in general.
How serious is the interaction between Nevirapine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and liver enzymes. Watch for inflammatory symptoms of immune reconstitution after starting therapy.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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