Drug interactions
Nicardipine + Nintedanib
Severity: Moderate
Nicardipine and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein in vitro and may raise nintedanib exposure. Higher levels could increase gastrointestinal effects, particularly diarrhea, and liver enzyme elevations. Clinical data are limited.
What this interaction means in plain words
Nicardipine and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by nicardipine reduces nintedanib efflux and increases exposure.
What to do
Monitor for diarrhea, nausea and liver enzyme elevation. Manage with dose reduction or interruption of nintedanib if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nicardipine and Nintedanib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nicardipine
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nicardipine with Nintedanib?
MediHelp rates the interaction as moderate. Nicardipine and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits P-glycoprotein in vitro and may raise nintedanib exposure. Higher levels could increase gastrointestinal effects, particularly diarrhea, and liver enzyme elevations. Clinical data are limited.
How serious is the interaction between Nicardipine and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, nausea and liver enzyme elevation. Manage with dose reduction or interruption of nintedanib if adverse effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
