Drug interactions
Nicardipine + Posaconazole
Severity: Moderate
Nicardipine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and can raise nicardipine concentrations, leading to excessive vasodilation with hypotension, flushing, headache and peripheral edema. The effect is typically manageable with dose adjustment.
What this interaction means in plain words
Nicardipine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of nicardipine by posaconazole.
What to do
Monitor blood pressure and heart rate and reduce the nicardipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Posaconazole?
MediHelp rates the interaction as moderate. Nicardipine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits CYP3A4 and can raise nicardipine concentrations, leading to excessive vasodilation with hypotension, flushing, headache and peripheral edema. The effect is typically manageable with dose adjustment.
How serious is the interaction between Nicardipine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the nicardipine dose if hypotension or edema occurs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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