Drug interactions
Nicardipine + Tasimelteon
Severity: Minor
Nicardipine and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine has CYP3A4 inhibitory activity and tasimelteon is partly metabolized by CYP3A4, so tasimelteon exposure might increase slightly. Clinical significance is likely small, with possible added somnolence or headache.
What this interaction means in plain words
Nicardipine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Tasimelteon belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP3A4-mediated tasimelteon metabolism by nicardipine.
What to do
No dose adjustment is routinely required. Monitor for increased daytime drowsiness or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Tasimelteon
Frequently asked questions
Can I take Nicardipine with Tasimelteon?
MediHelp rates the interaction as minor. Nicardipine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine has CYP3A4 inhibitory activity and tasimelteon is partly metabolized by CYP3A4, so tasimelteon exposure might increase slightly. Clinical significance is likely small, with possible added somnolence or headache.
How serious is the interaction between Nicardipine and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required. Monitor for increased daytime drowsiness or dizziness.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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