Drug interactions
Nicardipine + Tepotinib
Severity: Moderate
Nicardipine and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits intestinal P-glycoprotein, and nicardipine is a P-gp substrate, so nicardipine exposure may rise. This could cause excessive blood pressure lowering, flushing, headache, tachycardia or edema.
What this interaction means in plain words
Nicardipine and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-glycoprotein efflux, increasing absorption and reducing clearance of nicardipine.
What to do
Monitor blood pressure and heart rate when tepotinib is started or stopped, and reduce the nicardipine dose if hypotension or adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Nicardipine with Tepotinib?
MediHelp rates the interaction as moderate. Nicardipine and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits intestinal P-glycoprotein, and nicardipine is a P-gp substrate, so nicardipine exposure may rise. This could cause excessive blood pressure lowering, flushing, headache, tachycardia or edema.
How serious is the interaction between Nicardipine and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when tepotinib is started or stopped, and reduce the nicardipine dose if hypotension or adverse effects develop.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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