Drug interactions
Nicardipine + Toremifene
Severity: Moderate
Nicardipine and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a CYP3A4 inhibitor and may raise toremifene concentrations. Toremifene prolongs the QT interval in a dose-related way, so higher exposure could increase the risk of arrhythmia.
What this interaction means in plain words
Nicardipine and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Nicardipine inhibits CYP3A4, the main enzyme that metabolizes toremifene, reducing its clearance.
What to do
Obtain an ECG and check electrolytes, particularly potassium and magnesium, if the combination is used. Consider an alternative antihypertensive if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Nicardipine with Toremifene?
MediHelp rates the interaction as moderate. Nicardipine and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a CYP3A4 inhibitor and may raise toremifene concentrations. Toremifene prolongs the QT interval in a dose-related way, so higher exposure could increase the risk of arrhythmia.
How serious is the interaction between Nicardipine and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes, particularly potassium and magnesium, if the combination is used. Consider an alternative antihypertensive if QT prolongation develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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