Drug interactions
Nicardipine + Tucatinib
Severity: Major
Nicardipine and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and nicardipine is cleared largely by CYP3A4. Nicardipine levels can increase, causing hypotension, reflex tachycardia, peripheral edema and headache.
What this interaction means in plain words
Nicardipine and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nicardipine belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing first-pass and systemic metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate closely and start with a reduced nicardipine dose, or switch to an antihypertensive not metabolized by CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nicardipine
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Nicardipine with Tucatinib?
MediHelp rates the interaction as major. Nicardipine and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a strong CYP3A inhibitor and nicardipine is cleared largely by CYP3A4. Nicardipine levels can increase, causing hypotension, reflex tachycardia, peripheral edema and headache.
How serious is the interaction between Nicardipine and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely and start with a reduced nicardipine dose, or switch to an antihypertensive not metabolized by CYP3A4.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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