Drug interactions
Nicardipine + Vilazodone
Severity: Minor
Nicardipine and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may increase vilazodone concentrations through CYP3A4 inhibition. This could raise the risk of serotonergic and gastrointestinal adverse effects.
What this interaction means in plain words
Nicardipine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Vilazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 modestly reduces vilazodone metabolism.
What to do
Monitor for nausea, diarrhea and serotonergic symptoms. Reduce the vilazodone dose only if adverse effects occur, as the labeled reduction applies to strong inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Nicardipine with Vilazodone?
MediHelp rates the interaction as minor. Nicardipine and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may increase vilazodone concentrations through CYP3A4 inhibition. This could raise the risk of serotonergic and gastrointestinal adverse effects.
How serious is the interaction between Nicardipine and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nausea, diarrhea and serotonergic symptoms. Reduce the vilazodone dose only if adverse effects occur, as the labeled reduction applies to strong inhibitors.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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