Drug interactions
Nilotinib + Silodosin
Severity: Moderate
Nilotinib and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and P-glycoprotein and may raise silodosin exposure, increasing the risk of orthostatic hypotension. Nilotinib also prolongs QT but this is not relevant to silodosin's own effect.
What this interaction means in plain words
Nilotinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Silodosin belongs to Genitourinary.
Why it happens
Nilotinib inhibits CYP3A4 and P-glycoprotein, potentially reducing silodosin clearance.
What to do
Monitor blood pressure and orthostatic symptoms, and reduce exposure or switch the alpha-blocker if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Silodosin?
MediHelp rates the interaction as moderate. Nilotinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and P-glycoprotein and may raise silodosin exposure, increasing the risk of orthostatic hypotension. Nilotinib also prolongs QT but this is not relevant to silodosin's own effect.
How serious is the interaction between Nilotinib and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and reduce exposure or switch the alpha-blocker if hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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