Drug interactions
Nintedanib + Propafenone
Severity: Moderate
Nintedanib and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits P-glycoprotein, which may raise nintedanib exposure. This could increase gastrointestinal adverse effects, liver enzyme elevation and bleeding risk.
What this interaction means in plain words
Nintedanib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux of nintedanib by propafenone.
What to do
Monitor for nintedanib adverse effects and check liver enzymes regularly. Manage intolerance with dose reduction or temporary interruption of nintedanib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Propafenone?
MediHelp rates the interaction as moderate. Nintedanib and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits P-glycoprotein, which may raise nintedanib exposure. This could increase gastrointestinal adverse effects, liver enzyme elevation and bleeding risk.
How serious is the interaction between Nintedanib and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nintedanib adverse effects and check liver enzymes regularly. Manage intolerance with dose reduction or temporary interruption of nintedanib.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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